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Many thanks for your reply. I have found a solution to this issue for the benefit of others:

A thread discusses the issue here: http://www.apfelwiki.de/forum/viewtopic.php?f=6&t=1949&start=0&hilit=xelatex

This issue is related to the different font format used by Mac OS 10.6 and is resolved in ...

I'm having a problem being able to access variants of a particular font using the fontspec package. For example, when a word should be emboldened, it isn't and when a word should be emphasised, it also isn't.

I've written the following code TeXShop and typesetting using XeLaTeX:


\documentclass ...